Which of the following are contraindications to iontophoresis?

• A. Drug allergies
• B. Skin irritation at electrode site
• C. Both A and B
• D. None of the above

Answer: (C)

Iontophoresis delivers medication through the skin using a small electrical current, so safety hinges on the drug’s compatibility and the skin condition where the electrodes sit. If the patient has a drug allergy to the medication being delivered, using this route can trigger an allergic reaction, which could be localized or systemic. That makes it unsafe to proceed. Likewise, skin irritation at the electrode site means the skin is already compromised; the electrical current and the chemical effects of the drug can worsen irritation, potentially causing burns or dermatitis and unpredictable absorption. Intact, non-irritated skin is needed for safe and effective delivery. Because both conditions directly raise risk, they are contraindications to iontophoresis.